Technology Process of (3S,8S,E)-12-(tert-butyldiphenylsiloxy)-1-(4-methoxybenzyloxy)-3,8-dimethyldodec-10-en-4-yn-6-one
There total 13 articles about (3S,8S,E)-12-(tert-butyldiphenylsiloxy)-1-(4-methoxybenzyloxy)-3,8-dimethyldodec-10-en-4-yn-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/ol201547q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / Inert atmosphere
1.2: 0 °C / Inert atmosphere
1.3: 0 °C / Inert atmosphere; Saturated solution
2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve
With
n-butyllithium; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol201547q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium periodate / tetrahydrofuran; water / 0.17 h / 20 °C / Inert atmosphere
2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 0 °C / Inert atmosphere
4.2: 0 °C / Inert atmosphere
4.3: 0 °C / Inert atmosphere; Saturated solution
5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve
With
sodium periodate; n-butyllithium; tetrapropylammonium perruthennate; carbon tetrabromide; 4-methylmorpholine N-oxide; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1021/ol201547q
