1033074-22-4Relevant academic research and scientific papers
Synthesis of the C7-26 fragment of amphidinolides G and H
Hara, Akihiro,Morimoto, Ryo,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 4036 - 4039 (2011/10/04)
A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.
Asymmetric synthesis of β-alkynyl aldehydes by rhodium-catalyzed conjugate alkynylation
Nishimura, Takahiro,Sawano, Takahiro,Hayashi, Tamio
supporting information; experimental part, p. 8057 - 8059 (2010/01/16)
To the point: The rhodium-catalyzed asymmetric conjugate alkynylation of α, β-unsaturated aldehydes with triisopropylsilyl acetylene proceeded efficiently in methanol to give the β-alkynyl aldehydes in high yields with high enantioselectivity (see Scheme)
Synthesis of the ABC-ring models of goniodomin A: preference for the unnatural configuration at C11 of the BC-ring in a non-macrocyclic model system
Katagiri, Takahiro,Fujiwara, Kenshu,Kawai, Hidetoshi,Suzuki, Takanori
, p. 3242 - 3247 (2008/09/21)
To confirm the natural relative stereochemistry of the ABC-ring of goniodomin A (1), the corresponding three stereoisomeric compounds, (2R,5S,6S,7S,9S,11R,15S)-, (2R,5S,6S,7R,9R,11S,15R)-, and (2R,5S,6S,7R,9R,11R,15S)-isomers (2, 3, and 5, respectively),
