(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

Base Information

Chemical Name:(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine
CAS No.:943516-47-0
Molecular Formula:C₁₃H₁₄ClN₃OS
Molecular Weight:295.793
Hs Code.:

Synonyms:(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

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Chemical Property of (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

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Technology Process of (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

There total 1 articles about (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 50868-72-9
5-methoxy-o-toluidine

: 943516-47-0
(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 140 ℃;
DOI:10.1016/j.bmcl.2006.08.132

Reference yield: 67.0%

: 943516-47-0
(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

: 1073-32-1
sodium benzimidazolate

: 918870-35-6
(2-benzoimidazol-1-yl-6-chloro-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

Guidance literature:: (6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine; With oxone; In methanol; water;

sodium benzimidazolate; In N,N-dimethyl-formamide; at 60 ℃; microwave irradiation;
DOI:10.1016/j.bmcl.2006.08.132

Reference yield:

: 943516-47-0
(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

: 3-(2-benzoimidazol-1-yl-6-methoxy-pyrimidin-4-ylamino)-4-methyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Oxone(R) / methanol; H₂O

1.2: 67 percent / dimethylformamide / 60 °C / microwave irradiation

2.1: 50 percent / BBr₃ / CH₂Cl₂

3.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 100 °C / microwave irradiation

With oxone; boron tribromide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.08.132