Lck Inhibitor II

Base Information

Chemical Name:Lck Inhibitor II
CAS No.:918870-43-6
Molecular Formula:C₂₄H₂₆N₆O₃
Molecular Weight:446.509
Hs Code.:
Mol file:918870-43-6.mol

Synonyms:

Suppliers and Price of Lck Inhibitor II

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Alfa Aesar
Lck Inhibitor II
5mg
$ 273.00

Total 2 raw suppliers

Chemical Property of Lck Inhibitor II

Chemical Property:

Sensitive.:Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

Lck Inhibitor II ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor

Technology Process of Lck Inhibitor II

There total 4 articles about Lck Inhibitor II which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943516-47-0
(6-chloro-2-methylsulfanyl-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

: 918870-43-6
3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Oxone(R) / methanol; H₂O

1.2: 67 percent / dimethylformamide / 60 °C / microwave irradiation

2.1: 50 percent / BBr₃ / CH₂Cl₂

3.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 100 °C / microwave irradiation

With oxone; boron tribromide; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2006.08.132

Reference yield:

: 918870-35-6
(2-benzoimidazol-1-yl-6-chloro-pyrimidin-4-yl)-(5-methoxy-2-methyl-phenyl)-amine

: 918870-43-6
3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / BBr₃ / CH₂Cl₂

2: 1-methyl-pyrrolidin-2-one / 0.25 h / 100 °C / microwave irradiation

With boron tribromide; In 1-methyl-pyrrolidin-2-one; dichloromethane;
DOI:10.1016/j.bmcl.2006.08.132

Reference yield:

: 50868-72-9
5-methoxy-o-toluidine

: 918870-43-6
3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85 percent / Huenig's base / dimethylformamide / 140 °C

2.1: Oxone(R) / methanol; H₂O

2.2: 67 percent / dimethylformamide / 60 °C / microwave irradiation

3.1: 50 percent / BBr₃ / CH₂Cl₂

4.1: 1-methyl-pyrrolidin-2-one / 0.25 h / 100 °C / microwave irradiation

With oxone; boron tribromide; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.08.132