(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

Base Information

Chemical Name:(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate
CAS No.:1351186-14-5
Molecular Formula:C₂₉H₃₀F₃NO₅S₂
Molecular Weight:593.688
Hs Code.:

Synonyms:(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of (R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

There total 1 articles about (R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158861-38-2
(R)-N-methyl-N-methoxy-2-tert-butoxycarbonylamino-3-(triphenylmethylthio)propionamide

: 1351186-14-5
(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

With potassium hexamethylsilazane; In tetrahydrofuran; toluene;
DOI:10.1021/jo201951s

Reference yield: 96.0%

: 1351186-14-5
(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

: 1352233-31-8
(R)-tert-butyl (1-(tritylthio)but-3-en-2-yl)carbamate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; lithium chloride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere; Reflux;
DOI:10.1021/jo201951s

Reference yield:

: 1351186-14-5
(R)-3-(tert-butoxycarbonylamino)-4-(tritylthio)but-1-en-2-yl trifluoromethanesulfonate

: 1351186-41-8
(3R,4S)-8-((R)-N,2-dimethylbutanamido)-3,4-dimethyl-N-((R)-1-(tritylthio)but-3-en-2-yl)octanamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; lithium chloride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Reflux

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 5 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo201951s