N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide
CAS No.:538326-94-2
Molecular Formula:C₂₅H₁₅ClF₃NO₂S
Molecular Weight:485.914
Hs Code.:

Synonyms:N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

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Chemical Property of N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

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Technology Process of N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

There total 7 articles about N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 618-46-2
m-Chlorobenzoyl chloride

: 538326-91-9
N-(4,5-diphenylthiophen-2-yl)-2,2,2-trifluoroacetamide

: 538326-94-2
N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; Heating;
DOI:10.1021/jm020295m

Reference yield:

: 451-40-1
phenyl benzyl ketone

: 538326-94-2
N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; TiCl₄ / tetrahydrofuran / 0 - 20 °C

2: sulfur; Et₂NH / tetrahydrofuran / 1 h / 20 °C

3: aq. NaOH / ethanol / 48 h / Heating

4: Et₃N / CHCl₃ / 20 °C

5: 53 percent / SnCl₄ / 1,2-dichloro-ethane / Heating

With pyridine; sodium hydroxide; titanium tetrachloride; tin(IV) chloride; sulfur; diethylamine; triethylamine; In tetrahydrofuran; ethanol; chloroform; 1,2-dichloro-ethane; 1: Knoevenagel condensation / 5: Friedel-Crafts acylation;
DOI:10.1021/jm020295m

Reference yield:

: 4815-43-4
2-amino-4,5-diphenyl-thiophene-3-carboxylic acid ethyl ester

: 538326-94-2
N-[3-(3-chlorobenzoyl)-4,5-diphenylthiophen-2-yl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH / ethanol / 48 h / Heating

2: Et₃N / CHCl₃ / 20 °C

3: 53 percent / SnCl₄ / 1,2-dichloro-ethane / Heating

With sodium hydroxide; tin(IV) chloride; triethylamine; In ethanol; chloroform; 1,2-dichloro-ethane; 3: Friedel-Crafts acylation;
DOI:10.1021/jm020295m