(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

Base Information

Chemical Name:(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester
CAS No.:1373443-03-8
Molecular Formula:C₂₇H₂₉NO₄
Molecular Weight:431.532
Hs Code.:

Synonyms:(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

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Chemical Property of (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

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Technology Process of (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

There total 5 articles about (E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 4518-10-9
Methyl 3-aminobenzoate

: 1373443-30-1
(E)-3-(4-adamantan-1-yl-phenoxy)-acrylic acid

: 1373443-03-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm301419d

Reference yield:

: 29799-07-3
4-adamantylphenol

: 1373443-03-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / toluene / 3 h / -10 - 115 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm301419d

Reference yield:

: 1373443-26-5
(E)-3-(4-adamantan-1-yl-phenoxy)-acrylic acid methyl ester

: 1373443-03-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301419d