(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

Base Information

Chemical Name:(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester
CAS No.:1373443-14-1
Molecular Formula:C₃₀H₃₆N₂O₄
Molecular Weight:488.627
Hs Code.:

Synonyms:(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

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Chemical Property of (E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

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Technology Process of (E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

There total 4 articles about (E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.6%

: 1373443-11-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 1373443-14-1
(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm301419d

Reference yield:

: 1373443-03-8
(E)-3-[3-(4-adamantan-1-yl-phenoxy)-acryloylamino]-benzoic acid methyl ester

: 1373443-14-1
(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301419d

Reference yield:

: 29799-07-3
4-adamantylphenol

: 1373443-14-1
(E)-3-(3-(4-adamantan-1-yl-phenoxy)acrylamido)benzoic acid 2-(dimethylamino)ethylester

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine / toluene / 3 h / -10 - 115 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere

With lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm301419d