N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea

Base Information

• Chemical Name: N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea
• CAS No.: 108275-74-7
• Molecular Formula: C₂₃H₂₇BrN₂O₁₀S
• Molecular Weight: 603.445
• Mol file: 108275-74-7.mol

Synonyms:N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea

Chemical Property of N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea

There total 1 articles about N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

α-amino-4-bromoacetophenone hydrochloride (5467-72-1) + 2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate (14152-97-7,18866-59-6,93221-21-7,121959-10-2,121959-11-3,122564-52-7,41135-18-6) → N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea (108275-74-7)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; for 4h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90274-X

Reference yield: 49.0%

N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea (108275-74-7) → 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole (108275-81-6)

Guidance literature:

With phosphoric acid; In acetic anhydride; for 5h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90274-X

Reference yield:

N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea (108275-74-7) → 5-(p-bromophenyl)-2-(β-D-galactopyranosylamino)thiazole (108275-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / phosphoric acid / acetic anhydride / 5 h / Ambient temperature

2: 70 percent / 0.5percent sodium methoxide / methanol / 0.17 h / Ambient temperature

With phosphoric acid; sodium methylate; In methanol; acetic anhydride;

DOI:10.1016/S0008-6215(00)90274-X

upstream raw materials:

α-amino-4-bromoacetophenone hydrochloride

2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate

Downstream raw materials:

5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole

5-(p-bromophenyl)-2-(β-D-galactopyranosylamino)thiazole