5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole

Base Information

• Chemical Name: 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole
• CAS No.: 108275-81-6
• Molecular Formula: C₂₃H₂₅BrN₂O₉S
• Molecular Weight: 585.429
• Mol file: 108275-81-6.mol

Synonyms:5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole

Chemical Property of 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole

There total 3 articles about 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea (108275-74-7) → 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole (108275-81-6)

Guidance literature:

With phosphoric acid; In acetic anhydride; for 5h; Ambient temperature;

DOI:10.1016/S0008-6215(00)90274-X

Reference yield:

α-amino-4-bromoacetophenone hydrochloride (5467-72-1) → 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole (108275-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / sodium hydrogencarbonate / H₂O; acetone / 4 h / Ambient temperature

2: 49 percent / phosphoric acid / acetic anhydride / 5 h / Ambient temperature

With phosphoric acid; sodium hydrogencarbonate; In water; acetic anhydride; acetone;

DOI:10.1016/S0008-6215(00)90274-X

Reference yield:

2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate (14152-97-7,18866-59-6,93221-21-7,121959-10-2,121959-11-3,122564-52-7,41135-18-6) → 5-(p-bromophenyl)-2-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosylamino)thiazole (108275-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / sodium hydrogencarbonate / H₂O; acetone / 4 h / Ambient temperature

2: 49 percent / phosphoric acid / acetic anhydride / 5 h / Ambient temperature

With phosphoric acid; sodium hydrogencarbonate; In water; acetic anhydride; acetone;

DOI:10.1016/S0008-6215(00)90274-X

upstream raw materials:

N-(p-bromophenacyl)-N'-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)thiourea

α-amino-4-bromoacetophenone hydrochloride

2,3,4,6-tetra-O-Acetyl-β-D-galactopyranosyl isothiocyanate

Downstream raw materials:

5-(p-bromophenyl)-2-(β-D-galactopyranosylamino)thiazole