2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

Base Information

Chemical Name:2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one
CAS No.:259107-28-3
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

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Chemical Property of 2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

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Technology Process of 2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

There total 7 articles about 2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 259107-26-1
8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

: 259107-28-3
2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

Guidance literature:: With triethylsilane; titanium tetrachloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol990372g

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 259107-28-3
2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Et₃N; DMAP / CH₂Cl₂

2: 6 percent / TFA / CH₂Cl₂

3: 72 percent / H₂SO₄ / acetic acid / 1 h / 75 - 80 °C

4: 96 percent / Et₃SiH; TiCl₄ / CH₂Cl₂ / 24 h / 20 °C

With triethylsilane; dmap; sulfuric acid; titanium tetrachloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid; 1: Condensation / 2: Dehydration / 3: Prins reaction / 4: Reduction;
DOI:10.1021/ol990372g

Reference yield:

: 55109-47-2
3-methyl-2-oxobutanoyl chloride

: 259107-28-3
2S,5S,6R-4,5-dimethyl-6-phenyl-2-(1,1-dimethyl-2-methoxy ethyl) morpholin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / Et₃N; DMAP / CH₂Cl₂

2: 6 percent / TFA / CH₂Cl₂

3: 72 percent / H₂SO₄ / acetic acid / 1 h / 75 - 80 °C

4: 96 percent / Et₃SiH; TiCl₄ / CH₂Cl₂ / 24 h / 20 °C

With triethylsilane; dmap; sulfuric acid; titanium tetrachloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid; 1: Condensation / 2: Dehydration / 3: Prins reaction / 4: Reduction;
DOI:10.1021/ol990372g