8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Base Information

Chemical Name:8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one
CAS No.:259107-26-1
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Suppliers and Price of 8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

There total 4 articles about 8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 207223-32-3
(5S,6R)-2-(2-propylidene)-4,5-dimethyl-6-phenylmorpholine-3-one

: 259107-26-1
8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Guidance literature:: With sulfuric acid; In acetic acid; at 75 - 80 ℃; for 1h;
DOI:10.1021/ol990372g

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 259107-26-1
8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N; DMAP / CH₂Cl₂

2: 6 percent / TFA / CH₂Cl₂

3: 72 percent / H₂SO₄ / acetic acid / 1 h / 75 - 80 °C

With dmap; sulfuric acid; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid; 1: Condensation / 2: Dehydration / 3: Prins reaction;
DOI:10.1021/ol990372g

Reference yield:

: 55109-47-2
3-methyl-2-oxobutanoyl chloride

: 259107-26-1
8R,6R,9S,5,5,9,10-tetramethyl-1,3,7-trioxa-10-aza-spiro[5,5]undecan-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N; DMAP / CH₂Cl₂

2: 6 percent / TFA / CH₂Cl₂

3: 72 percent / H₂SO₄ / acetic acid / 1 h / 75 - 80 °C

With dmap; sulfuric acid; triethylamine; trifluoroacetic acid; In dichloromethane; acetic acid; 1: Condensation / 2: Dehydration / 3: Prins reaction;
DOI:10.1021/ol990372g