(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Base Information

Chemical Name:(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one
CAS No.:1208110-12-6
Molecular Formula:C₂₃H₂₆FNO₂
Molecular Weight:367.463
Hs Code.:

Synonyms:(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Suppliers and Price of (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

There total 21 articles about (2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (2S)-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one

: 467223-91-2
1-fluoro-3-(2-iodoethyl)benzene

: 1208110-12-6
(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Guidance literature:: (2S)-6-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one; With potassium carbonate; N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 1h;

1-fluoro-3-(2-iodoethyl)benzene; In toluene; for 72h; Reflux;
DOI:10.1016/j.bmc.2017.05.012

Reference yield:

: 71413-04-2
(2RS)-1-benzoylpiperidine-2-carbonitrile

: 1208110-12-6
(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / toluene / 4 h / 20 °C

2.2: 18 h / 120 °C

3.1: di-isopropyl ether; ethanol / 18 h / 20 °C

4.1: sodium hydroxide / ethyl acetate

5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / toluene / 1 h / 20 °C

5.2: 72 h / Reflux

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; di-isopropyl ether; ethyl acetate; toluene;
DOI:10.1016/j.bmc.2017.05.012

Reference yield:

: 78348-46-6
N-benzoyl-2-piperidinecarboxylic acid

: 1208110-12-6
(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / -20 - -15 °C

1.2: 3 h / 20 °C

2.1: trichlorophosphate; pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 27 h / 0 - 80 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / toluene / 4 h / 20 °C

4.2: 18 h / 120 °C

5.1: di-isopropyl ether; ethanol / 18 h / 20 °C

6.1: sodium hydroxide / ethyl acetate

7.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / toluene / 1 h / 20 °C

7.2: 72 h / Reflux

With pyridine; chloroformic acid ethyl ester; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; ethanol; di-isopropyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2017.05.012