FMOC-AMINOXYACETIC ACID

Base Information

• Chemical Name: FMOC-AMINOXYACETIC ACID
• CAS No.: 123106-21-8
• Molecular Formula: C17H15 N O5
• Molecular Weight: 313.3
• Hs Code.: 29225090
• Mol file: 123106-21-8.mol

Synonyms:Aceticacid, [[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]oxy]- (9CI);[[[[(9-Fluorenyl)methoxy]carbonyl]amino]oxy]acetic acid

Chemical Property of FMOC-AMINOXYACETIC ACID

Chemical Property:

• PKA: 2.89±0.10(Predicted)
• PSA: 84.86000
• Density: 1.349±0.06 g/cm3(Predicted)
• LogP: 2.93220
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-aminoxyacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-AMINOXYACETIC ACID

There total 4 articles about FMOC-AMINOXYACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (aminooxy)acetic acid hemihydrochloride (2921-14-4,7776-18-3,20295-82-3) → 2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oxy)acetic acid (123106-21-8)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1016/S0040-4020(00)00577-9

Reference yield: 84.0%

2-(aminooxy)acetic acid hemihydrochloride + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oxy)acetic acid (123106-21-8)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2012.09.016

Reference yield: 78.0%

2-(aminooxy)acetic acid hemihydrochloride + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → 2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oxy)acetic acid (123106-21-8)

Guidance literature:

2-(aminooxy)acetic acid hemihydrochloride; (fluorenylmethoxy)carbonyl chloride; With sodium carbonate; In 1,4-dioxane; water; at 10 - 35 ℃; for 4.25h;

With water; citric acid; In ethyl acetate;

DOI:10.1016/j.bmc.2009.06.038

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(aminooxy)acetic acid hemihydrochloride

O-carboxymethylhydroxylamine hydrochloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

5'-[2-[(N-fluorenemethyloxycarbonyl)-aminooxy]]-acetylamino-N-benzoyl-2',5'-dideoxyadenosine

Refernces

• 1、 Pfeiffer, Hendrik,Sowik, Thomas,Schatzschneider, Ulrich. "Bioorthogonal oxime ligation of a Mo(CO)4(N-N) CO-releasing molecule (CORM) to a TGF β-binding peptide". supporting information. p. 17 - 24. Retrieved 2013/06/27.
• 2、 Sethi,Patnaik,Kumar,Gandhi,Gupta,Kumar. "Polymer supported synthesis of aminooxyalkylated oligonucleotides, and some applications in the fabrication of microarrays". experimental part. p. 5442 - 5450. Retrieved 2009/12/06.