1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

Base Information

• Chemical Name: 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole
• CAS No.: 127451-67-6
• Molecular Formula: C₂₅H₃₂BrNO₂
• Molecular Weight: 458.439
• Mol file: 127451-67-6.mol

Synonyms:1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

Chemical Property of 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

There total 2 articles about 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1,8-dibromooctane (4549-32-0) + 5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole (91444-18-7) → 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole (127451-67-6)

Guidance literature:

5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.25h;

1,8-dibromooctane; In tetrahydrofuran; mineral oil; for 2h; Reflux;

DOI:10.1016/j.bmc.2016.06.050

Reference yield:

4-Methoxypropiophenone (121-97-1) → 1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole (127451-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol / 6 h / 80 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C

2.2: 2 h / Reflux

With hydrogenchloride; sodium hydride; In tetrahydrofuran; ethanol; mineral oil;

DOI:10.1016/j.bmc.2016.06.050

Reference yield: 66.0%

1-(8-bromooctyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole (127451-67-6) + methylamine (74-89-5) → 8-(5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indol-1-yl)-N-methyloctan-1-amine

Guidance literature:

In tetrahydrofuran; at 65 ℃; for 48h; Sealed tube;

DOI:10.1016/j.bmc.2016.06.050

upstream raw materials:

1,8-dibromooctane

5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole

4-Methoxypropiophenone

Downstream raw materials:

5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-1-(8-pyrrolidin-1-yl-octyl)-1H-indole

5-acetoxy-2-(4-acetoxyphenyl)-1-(8-bromooctyl)-3-methylindole

2-(4-Hydroxy-phenyl)-3-methyl-1-(8-pyrrolidin-1-yl-octyl)-1H-indol-5-ol