5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

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Chemical Name:5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
CAS No.:865479-48-7
Molecular Formula:C₂₁H₂₂BF₂N₃O
Molecular Weight:381.233
Hs Code.:

Synonyms:5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

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Chemical Property of 5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

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Technology Process of 5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

There total 2 articles about 5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 865479-55-6
5-(4-morpholinophenyl)-1,9-dimethyldipyrromethene

: 109-63-7
trifluoroborane diethyl ether

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 865479-48-7
5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: In dichloromethane; dipyrromethene (0.5 mol) dissolved in CH2Cl2, DIEA (16 mmol) added, stirred at room temp. for 20 min (Ar), BF3*OEt2 (20 mmol) added dropwise, stirred for 1 h; mixt. washed (H2O, 2 N NaOH), aq. soln. extd. (CH2Cl2), dried over MgSO4, filtered, evapd., chromy. on silica gel (ethyl acetate/hexane 3/7 v/v), recrystd. (hexane/CHCl3);
DOI:10.1021/jp052626n

Reference yield: 11.0%

: 636-41-9
2-methyl-1H-pyrrole

: 1204-86-0
4-(4-morpholinyl)benzaldehyde

: 109-63-7
boron trifluoride diethyl etherate

: 865479-48-7
5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

Guidance literature:: 2-methyl-1H-pyrrole; 4-(4-morpholinyl)benzaldehyde; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 2h;

boron trifluoride diethyl etherate; Further stages;
DOI:10.1016/j.dyepig.2017.10.018