Technology Process of 5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide
There total 2 articles about 5,5-difluoro-3,7-dimethyl-10-(4-morpholinophenyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
dichloromethane;
dipyrromethene (0.5 mol) dissolved in CH2Cl2, DIEA (16 mmol) added, stirred at room temp. for 20 min (Ar), BF3*OEt2 (20 mmol) added dropwise, stirred for 1 h; mixt. washed (H2O, 2 N NaOH), aq. soln. extd. (CH2Cl2), dried over MgSO4, filtered, evapd., chromy. on silica gel (ethyl acetate/hexane 3/7 v/v), recrystd. (hexane/CHCl3);
DOI:10.1021/jp052626n
- Guidance literature:
-
2-methyl-1H-pyrrole; 4-(4-morpholinyl)benzaldehyde;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 20h;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
for 2h;
boron trifluoride diethyl etherate;
Further stages;
DOI:10.1016/j.dyepig.2017.10.018
