3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

Base Information

Chemical Name:3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine
CAS No.:99573-31-6
Molecular Formula:C₁₈H₁₇BrN₂O₅
Molecular Weight:421.247
Hs Code.:

Synonyms:3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

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Chemical Property of 3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

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Technology Process of 3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

There total 1 articles about 3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 92611-31-9
3-amino-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

: 75-36-5
acetyl chloride

: 99573-31-6
3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 50 ℃; for 22h;
DOI:10.1021/jo00350a070

Reference yield: 98.0%

: 99573-31-6
3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

: 99604-70-3
3-acetamido-4-(2-bromophenyl)-6-(methoxycarbonyl)-5-methylpyridine-2-carboxylic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jo00350a070

Reference yield:

: 99573-31-6
3-acetamido-4-(2-bromophenyl)-2,6-bis(methoxycarbonyl)-5-methylpyridine

: 99604-74-7
1-(8-(benzyloxy)-7-bromo-2-quinolinyl)-3-(methoxycarbonyl)-4-methyl-β-carboline

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / sodium hydride / tetrahydrofuran / 4 h / Heating

2: 100 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 0 °C

3: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 40 min

4: aluminum amalgam / tetrahydrofuran; H₂O / 0.25 h / -15 - -10 °C

5: 54 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / dioxane / 18 h / 100 °C

6: 52 percent / benzyltrimethylammonium hydroxide (Triton B) / methanol; tetrahydrofuran / 18 h / 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; aluminium amalgam; N-benzyl-trimethylammonium hydroxide; sodium hydride; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/jo00350a070