(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Base Information

Chemical Name:(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol
CAS No.:1376514-49-6
Molecular Formula:C₂₄H₃₉N₅O₃
Molecular Weight:445.605
Hs Code.:

Synonyms:(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Suppliers and Price of (3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

There total 15 articles about (3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1376514-48-5
N₄-[(3S)-1-(benzyloxy)hexan-3-yl]-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidine-2,4-diamine

: 1376514-49-6
(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: N₄-[(3S)-1-(benzyloxy)hexan-3-yl]-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidine-2,4-diamine; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

With potassium carbonate; In water;

Reference yield:

: 18278-34-7
4-hydroxy-2-methoxybenzaldehyde

: 1376514-49-6
(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride; lithium chloride / tetrahydrofuran / 0.67 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 6 h / 80 °C

5.1: methanol / 8 h / 75 °C

6.1: N,N,N'N'-tetramethyl-1,3-propanediamine / tetrahydrofuran / 3 h / 20 °C

7.1: trifluoroacetic acid / 15 h / 120 °C

8.1: hydrogenchloride / water; methanol / 1 h / 20 °C

9.1: triethylamine / tetrahydrofuran / 0 °C

10.1: acetonitrile; water / 1.5 h / 80 °C

11.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N,N,N'N'-tetramethyl-1,3-propanediamine; hydrogen; sodium hydride; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 64197-80-4
(S)-(+)-3-amino-1-hexanol

: 1376514-49-6
(3S)-3-[(2-amino-5-{4-[3-(dimethylamino)propoxy]-2-methoxybenzyl}-6-methylpyrimidin-4-yl)amino]hexan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / 1,4-dioxane; water / 2 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C

3: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

4: trifluoroacetic acid / 15 h / 120 °C

5: hydrogenchloride / water; methanol / 1 h / 20 °C

6: triethylamine / tetrahydrofuran / 0 °C

7: acetonitrile; water / 1.5 h / 80 °C

8: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;