ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate
CAS No.:1417449-01-4
Molecular Formula:C₁₉H₁₆Cl₂N₂O₂
Molecular Weight:375.254
Hs Code.:

Synonyms:ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

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Chemical Property of ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

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Technology Process of ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

There total 4 articles about ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13123-92-7
(2,4-dichlorophenyl)hydrazine

: ethyl 3-methyl-4-phenyl-2,4-dioxobutanoate

: 1417449-01-4
ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

: 221385-23-5
1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: (2,4-dichlorophenyl)hydrazine; ethyl 3-methyl-4-phenyl-2,4-dioxobutanoate; With acetic acid; In tetrahydrofuran; for 8h; Inert atmosphere; Reflux;

With acetyl chloride; In tetrahydrofuran; for 8h; Overall yield = 1.46 g; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.11.012

Reference yield:

: 93-55-0
1-phenyl-propan-1-one

: 1417449-01-4
ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

: 221385-23-5
1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium tert-butoxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: acetic acid / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2.2: 8 h / Inert atmosphere; Reflux

With acetic acid; lithium tert-butoxide; In tetrahydrofuran; 1.1: |Claisen Condensation / 2.2: |Knorr Pyrazole Synthesis;
DOI:10.1016/j.tet.2012.11.012