1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester
CAS No.:221385-23-5
Molecular Formula:C₁₉H₁₆Cl₂N₂O₂
Molecular Weight:375.254
Hs Code.:
Mol file:221385-23-5.mol

Synonyms:1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Suppliers and Price of 1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2,4-Dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylicAcidEthylEster
100mg
$ 165.00

Medical Isotopes, Inc.
1-(2,4-Dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylicAcidEthylEster
1 g
$ 2200.00

American Custom Chemicals Corporation
1-(2,4-DICHLOROPHENYL)-4-METHYL-5-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 457.95

Total 1 raw suppliers

Chemical Property of 1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Melting Point:80-82 °C
Boiling Point:501.3±50.0 °C(Predicted)
PKA:-2.25±0.10(Predicted)
Density:1.29±0.1 g/cm3(Predicted)
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:: 1-(2,4-Dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 1-(2,4-Dichlorophenyl)-4-Methyl-5-phenyl-1H-pyrazole-3-carboxylic Acid Ethyl Ester can be used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists.

Technology Process of 1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

There total 7 articles about 1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221385-22-4
ethyl 3-methyl-2,4-dioxo-4-phenylbutanoate lithium salt

: 13123-92-7
(2,4-dichlorophenyl)hydrazine

: 221385-23-5
1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: With sulfuric acid; In ethanol; at 80 ℃; for 8h; Cooling with ice;
DOI:10.1016/j.ejmech.2015.06.010

Reference yield:

: 93-55-0
1-phenyl-propan-1-one

: 95-92-1
oxalic acid diethyl ester

: 13123-92-7
(2,4-dichlorophenyl)hydrazine

: 221385-23-5
1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: 1-phenyl-propan-1-one; With lithium hexamethyldisilazane; In methyl cyclohexane; at 20 ℃; for 3h;

oxalic acid diethyl ester; In methyl cyclohexane; for 16h;

(2,4-dichlorophenyl)hydrazine; With sulfuric acid; In ethanol; Cooling with ice; Reflux;
DOI:10.1016/j.ejmech.2013.07.054

Reference yield:

: 13123-92-7
(2,4-dichlorophenyl)hydrazine

: ethyl 3-methyl-4-phenyl-2,4-dioxobutanoate

: 1417449-01-4
ethyl 1-(2,4-dichlorophenyl)-4-methyl-3-phenyl-1H-pyrazole-5-carboxylate

: 221385-23-5
1-(2,4-dichlorophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: (2,4-dichlorophenyl)hydrazine; ethyl 3-methyl-4-phenyl-2,4-dioxobutanoate; With acetic acid; In tetrahydrofuran; for 8h; Inert atmosphere; Reflux;

With acetyl chloride; In tetrahydrofuran; for 8h; Overall yield = 1.46 g; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.11.012