4-nitrobenzo[d]oxazole-2-thiol

Base Information

• Chemical Name: 4-nitrobenzo[d]oxazole-2-thiol
• CAS No.: 101495-34-5
• Molecular Formula: C₇H₄N₂O₃S
• Molecular Weight: 196.186
• Mol file: 101495-34-5.mol

Synonyms:4-nitrobenzo[d]oxazole-2-thiol

Chemical Property of 4-nitrobenzo[d]oxazole-2-thiol

Chemical Property:

• Melting Point: 220 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 337.4±44.0 °C(Predicted)
• Density: 1.65±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-Nitro-3H-benzooxazole-2-thione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzo[d]oxazole-2-thiol

There total 5 articles about 4-nitrobenzo[d]oxazole-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

carbon disulfide (75-15-0,12122-00-8) + 2-Amino-3-nitrophenol (603-85-0) → 4-nitro-3H-benzooxazole-2-thione (101495-34-5)

Guidance literature:

carbon disulfide; 2-Amino-3-nitrophenol; With potassium hydroxide; In ethanol; water; Heating / reflux;

With hydrogenchloride; water; In ethanol;

Reference yield: 41.0%

thiophosgene (463-71-8) + 2-Amino-3-nitrophenol (603-85-0) → 4-nitrobenzo[d]oxazole-2-thiol (101495-34-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

Reference yield: 14.0%

2-Amino-3-nitrophenol (603-85-0) + potassium ethyl xanthogenate (140-89-6) → 4-nitrobenzo[d]oxazole-2-thiol (101495-34-5)

Guidance literature:

2-Amino-3-nitrophenol; potassium ethyl xanthogenate; In ethanol; Reflux;

With acetic acid; In water; pH=5;

DOI:10.1016/j.bmc.2009.12.074

upstream raw materials:

thiophosgene

2-Amino-3-nitrophenol

carbon disulfide

potassium ethyl xanthogenate

Downstream raw materials:

4-(4-nitrobenzoxazol-2-yl)piperazine-1-carboxylic acid benzyl ester

N-(2,6-diisopropylphenyl)-6-((4-nitrobenzo[d]oxazol-2-yl)thio)hexanamide

N-(2,6-diisopropylphenyl)-6-(4-aminobenzoxazol-2-ylthio)hexanamide