2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid

Base Information

• Chemical Name: 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid
• CAS No.: 1429347-18-1
• Molecular Formula: C₁₉H₂₂BrNO₄S
• Molecular Weight: 440.358
• Mol file: 1429347-18-1.mol

Synonyms:2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid

Chemical Property of 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid

There total 6 articles about 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-bromo-5-(chlorosulfonyl)benzoic acid (3285-31-2) + 4-ethyl-N-(2-methylpropyl)aniline → 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid (1429347-18-1) + C31H39BrN2O3S

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.oprd.9b00147

Reference yield:

methyl 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoate (1429347-62-5) → 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid (1429347-18-1)

Guidance literature:

methyl 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoate; With -butyl vinyl ether; palladium diacetate; triethylamine; triphenylphosphine; In acetonitrile; at 150 ℃; for 1h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; water; for 1h;

Reference yield:

4-aminoethylbenzene (589-16-2) → 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoic acid (1429347-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium iodide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] / water / 1.5 h / 150 °C / Microwave irradiation

2.1: pyridine / 17 h / 20 °C

3.1: triethylamine; triphenylphosphine; -butyl vinyl ether; palladium diacetate / acetonitrile / 1 h / 150 °C / Microwave irradiation

3.2: 1 h

With pyridine; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; -butyl vinyl ether; palladium diacetate; triethylamine; triphenylphosphine; potassium iodide; In water; acetonitrile;

upstream raw materials:

4-aminoethylbenzene

methyl 2-bromo-5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)benzoate

2-bromo-5-(chlorosulfonyl)benzoic acid

2-bromobenzoic-acid

Downstream raw materials:

N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide