4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Base Information

• Chemical Name: 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide
• CAS No.: 117536-01-3
• Molecular Formula: C₂₄H₃₂N₂O₄
• Molecular Weight: 412.529
• Mol file: 117536-01-3.mol

Synonyms:4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Chemical Property of 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

There total 5 articles about 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117535-97-4) → 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117536-01-3)

Guidance literature:

With potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 5h; pressure vessel;

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117536-01-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / K₂CO₃ / acetone / 40 h / Heating

2: 65 percent / 1N NaOH / 20 h / Ambient temperature

3: 75 percent / SOCl₂ / 6 h / Heating

4: 82 percent / sodium acetate / CHCl₃; H₂O / Ambient temperature; overnight

5: 76 percent / KI / dimethylformamide / 5 h / 100 °C / pressure vessel

With sodium hydroxide; thionyl chloride; sodium acetate; potassium carbonate; potassium iodide; In chloroform; water; N,N-dimethyl-formamide; acetone;

Reference yield:

4-(3-chloropropoxy)phenylacetic acid (69182-93-0) → 4-<3-(N-hydroxyethyl-N-methyl)propoxy>-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide (117536-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / SOCl₂ / 6 h / Heating

2: 82 percent / sodium acetate / CHCl₃; H₂O / Ambient temperature; overnight

3: 76 percent / KI / dimethylformamide / 5 h / 100 °C / pressure vessel

With thionyl chloride; sodium acetate; potassium iodide; In chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

4-(3-chloropropoxy)-N-<3-(4-phenyl-2-oxobutyl)>phenylacetamide

Methyl 4-hydroxyphenylacetate

4-(3-chloropropoxy)phenylacetic acid

Downstream raw materials:

3-<4-<3-(N-hydroxyethyl-N-methyl)aminopropoxy>phenyl>-4-methyl-5-benzylidenepyrrolin-2-one