C₂₁H₂₆F₇NOSi

Base Information

• Chemical Name: C₂₁H₂₆F₇NOSi
• CAS No.: 1425052-58-9
• Molecular Formula: C₂₁H₂₆F₇NOSi
• Molecular Weight: 469.518
• Mol file: 1425052-58-9.mol

Synonyms:C₂₁H₂₆F₇NOSi

Chemical Property of C₂₁H₂₆F₇NOSi

Chemical Property:

Purity/Quality:

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Technology Process of C₂₁H₂₆F₇NOSi

There total 1 articles about C₂₁H₂₆F₇NOSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide (1217507-32-8) + 1-bromo-2-(tert-butyldimethylsilyl)acetylene (708208-01-9) → C21H26F7NOSi (1425052-58-9)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); C₂₃H₃₃N₂⁽¹⁺⁾*BF₄^(1-); caesium carbonate; In diethyl ether; at 20 - 85 ℃; for 8.08333h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja400648w

Reference yield: 80.0%

C21H26F7NOSi (1425052-58-9) → 2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide (1425052-62-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ja400648w

upstream raw materials:

2-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pentanamide

1-bromo-2-(tert-butyldimethylsilyl)acetylene

Downstream raw materials:

2-propyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)pent-4-ynamide