(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Base Information

Chemical Name:(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride
CAS No.:145902-36-9
Molecular Formula:C₁₈H₁₉NO₄*ClH
Molecular Weight:349.814
Hs Code.:

Synonyms:(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Suppliers and Price of (S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

There total 6 articles about (S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 145902-59-6
(S)-4-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-2-oxo-butyric acid methyl ester

: 145902-36-9
(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; Ambient temperature;
DOI:10.1021/jm00054a004

Reference yield:

: 27513-44-6
N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester

: 145902-36-9
(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminium hydride / toluene; hexane / -77 °C

2: sodium metabisulfite / H₂O / 5 h / Ambient temperature

3: 1.) 25percent aq. HCl, 2.) Na₂CO₃, di-tert-butyl dicarbonate, 3.) KHCO₃

4: 44 percent / Cs₂CO₃, (n-Bu)4NI / dimethylformamide / 5 h

5: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -77 deg C, 20 min, 2.) CH₂Cl₂, -77 deg C, 10 min

6: 67 percent / HCl (gas) / diethyl ether / Ambient temperature

With hydrogenchloride; sodium disulfite; oxalyl dichloride; di-tert-butyl dicarbonate; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; sodium carbonate; potassium hydrogencarbonate; caesium carbonate; dimethyl sulfoxide; triethylamine; In diethyl ether; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00054a004

Reference yield:

: 82689-15-4
O-benzyl-N-(tert-butoxycarbonyl)-L-tyrosinal

: 145902-36-9
(S)-3-Amino-4-(4-benzyloxy-phenyl)-2-oxo-butyric acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium metabisulfite / H₂O / 5 h / Ambient temperature

2: 1.) 25percent aq. HCl, 2.) Na₂CO₃, di-tert-butyl dicarbonate, 3.) KHCO₃

3: 44 percent / Cs₂CO₃, (n-Bu)4NI / dimethylformamide / 5 h

4: 1.) DMSO, (COCl)2, 2.) Et₃N / 1.) CH₂Cl₂, -77 deg C, 20 min, 2.) CH₂Cl₂, -77 deg C, 10 min

5: 67 percent / HCl (gas) / diethyl ether / Ambient temperature

With hydrogenchloride; sodium disulfite; oxalyl dichloride; di-tert-butyl dicarbonate; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium hydrogencarbonate; caesium carbonate; dimethyl sulfoxide; triethylamine; In diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00054a004