5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Base Information

Chemical Name:5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate
CAS No.:194928-63-7
Molecular Formula:C₃₇H₃₃Cl₂N₅O₆
Molecular Weight:714.605
Hs Code.:

5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Synonyms:5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

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Chemical Property of 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

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Technology Process of 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

There total 7 articles about 5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

: 160648-19-1
(E)-3-[6-(ethoxycarbonyl)pyridin-3-yl]acrylic acid

: 194928-62-6
2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

: 194928-63-7
5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm030468n

Reference yield:

: 586-98-1
2-Hydroxymethylpyridine

: 194928-63-7
5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / cooling

1.2: 49.2 percent / various solvent(s) / 100 °C

2.1: NaH / dimethylformamide / 0.5 h / cooling

2.2: 772 mg / dimethylformamide / 24 h / 20 °C

3.1: 65.2 percent / hydrazine monohydrate / ethanol / 4 h / Heating

4.1: 66.2 percent / 1-hydroxybenzotriazole; 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide / 20 °C

With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n

Reference yield:

: 28507-46-2
4-chloro-8-hydroxy-2-methylquinoline

: 194928-63-7
5-[(1E)-3-({2-[2,4-dichloro(methyl)-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)anilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / cooling

1.2: 49.2 percent / various solvent(s) / 100 °C

2.1: NaH / dimethylformamide / 0.5 h / cooling

2.2: 772 mg / dimethylformamide / 24 h / 20 °C

3.1: 65.2 percent / hydrazine monohydrate / ethanol / 4 h / Heating

4.1: 66.2 percent / 1-hydroxybenzotriazole; 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl / dimethylformamide / 20 °C

With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n