2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

Base Information

Chemical Name:2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide
CAS No.:194928-62-6
Molecular Formula:C₂₆H₂₄Cl₂N₄O₃
Molecular Weight:511.408
Hs Code.:

Synonyms:2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

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Chemical Property of 2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

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Technology Process of 2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

There total 16 articles about 2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.2%

: 194928-61-5
N-[2,4-dichloro-3-({[2-methyl-4-(2-pyridinylmethoxy)-8-quinolinyl]oxy}methyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-methylacetamide

: 194928-62-6
2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

Guidance literature:: With hydrazine hydrate; In ethanol; for 4h; Heating;
DOI:10.1021/jm030468n

Reference yield:

: 586-98-1
2-Hydroxymethylpyridine

: 194928-62-6
2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / cooling

1.2: 49.2 percent / various solvent(s) / 100 °C

2.1: NaH / dimethylformamide / 0.5 h / cooling

2.2: 772 mg / dimethylformamide / 24 h / 20 °C

3.1: 65.2 percent / hydrazine monohydrate / ethanol / 4 h / Heating

With sodium hydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n

Reference yield:

: 167837-48-1
N-(2,4-dichloro-3-(hydroxymethyl)phenyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylacetamide

: 194928-62-6
2-amino-N-(2,4-dichloro-3-(((2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl)oxy)methyl)phenyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonyl chloride; Et₃N / CH₂Cl₂ / 0.5 h

2.1: NaH / dimethylformamide / 0.5 h / cooling

2.2: 772 mg / dimethylformamide / 24 h / 20 °C

3.1: 65.2 percent / hydrazine monohydrate / ethanol / 4 h / Heating

With sodium hydride; hydrazine hydrate; methanesulfonyl chloride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n