1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole

Base Information

• Chemical Name: 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole
• CAS No.: 102390-50-1
• Molecular Formula: C₁₈H₁₈N₂O
• Molecular Weight: 278.354
• Mol file: 102390-50-1.mol

Synonyms:1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole

Chemical Property of 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole

There total 4 articles about 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-(1-imidazolyl)-3-phenyl-propan-3-one (28918-16-3) → 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole (102390-50-1)

Guidance literature:

phenyl halide; With iodine; magnesium; In diethyl ether; for 1h; Reflux;

1-(1-imidazolyl)-3-phenyl-propan-3-one; In tetrahydrofuran; for 18h; Reflux;

DOI:10.1002/ardp.201000224

Reference yield: 50.0%

phenylmagnesium bromide (100-58-3) + 1-(1-imidazolyl)-3-phenyl-propan-3-one (28918-16-3) → 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole (102390-50-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1021/jm800009r

Reference yield:

3-(dimethylamino)propiophenone hydrochloride (879-72-1) → 1-(3,3-diphenyl-3-hydroxypropyl)-1H-imidazole (102390-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water / 5 h / Reflux

2.1: iodine; magnesium / diethyl ether / 1 h / Reflux

2.2: 18 h / Reflux

With iodine; magnesium; In diethyl ether; water;

DOI:10.1002/ardp.201000224

upstream raw materials:

phenylmagnesium bromide

1-(1-imidazolyl)-3-phenyl-propan-3-one

3-(dimethylamino)propiophenone hydrochloride

acetophenone