5-phenyl pyrrole-2,3-dicarboxylate de diethyle

Base Information

• Chemical Name: 5-phenyl pyrrole-2,3-dicarboxylate de diethyle
• CAS No.: 57927-94-3
• Molecular Formula: C₁₆H₁₇NO₄
• Molecular Weight: 287.315
• Mol file: 57927-94-3.mol

Synonyms:5-phenyl pyrrole-2,3-dicarboxylate de diethyle

Chemical Property of 5-phenyl pyrrole-2,3-dicarboxylate de diethyle

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-phenyl pyrrole-2,3-dicarboxylate de diethyle

There total 9 articles about 5-phenyl pyrrole-2,3-dicarboxylate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C18H19NO5 (1604842-55-8) → 5-phenyl pyrrole-2,3-dicarboxylate de diethyle (57927-94-3)

Guidance literature:

With potassium carbonate; triethylamine; In toluene; at 120 ℃;

DOI:10.1002/chem.201304565

Reference yield: 79.0%

acetophenone O-acetyloxime (19433-17-1) + acetylenedicarboxylic acid diethyl ester (762-21-0) → 5-phenyl pyrrole-2,3-dicarboxylate de diethyle (57927-94-3)

Guidance literature:

With oxygen; copper(l) chloride; sodium sulfite; In dimethyl sulfoxide; at 120 ℃; for 12h;

DOI:10.1039/c3cc44896g

Reference yield: 75.0%

N-(1-phenylvinyl)acetamide (57957-24-1) + acetylenedicarboxylic acid diethyl ester (762-21-0) → 5-phenyl pyrrole-2,3-dicarboxylate de diethyle (57927-94-3)

Guidance literature:

With oxygen; copper diacetate; potassium carbonate; triethylamine; In 1,2-dichloro-ethane; at 120 ℃; for 24h; Reagent/catalyst; Solvent;

DOI:10.1002/chem.201304565

upstream raw materials:

5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle

acetophenone

3-dimethylaminopropiophenone

acetophenone O-acetyloxime