5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle

Base Information

• Chemical Name: 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle
• CAS No.: 2851-46-9
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 2851-46-9.mol

Synonyms:5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle

Chemical Property of 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle

There total 5 articles about 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

1-azidostyrene (16717-64-9) + 1,3-diethyl 2-diazopropanedioate (5256-74-6) → 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle (2851-46-9) + benzonitrile (100-47-0)

Guidance literature:

With dirhodium tetraacetate; In chloroform-d1; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201801976

Reference yield:

1-(1-azido-2-iodoethyl)benzene (4098-17-3) → 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle (2851-46-9) + benzonitrile (100-47-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / diethyl ether / 0 °C

2: dirhodium tetraacetate / chloroform-d1 / 4 h / 65 °C / Inert atmosphere

With dirhodium tetraacetate; potassium tert-butylate; In diethyl ether; chloroform-d1;

DOI:10.1002/anie.201801976

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 5-phenyl-3,4-dihydro 2H pyrrole-2,2-dicarboxylate de diethyle (2851-46-9) + benzonitrile (100-47-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Iodine monochloride; sodium azide / dichloromethane / -20 °C

2: potassium tert-butylate / diethyl ether / 0 °C

3: dirhodium tetraacetate / chloroform-d1 / 4 h / 65 °C / Inert atmosphere

With dirhodium tetraacetate; sodium azide; potassium tert-butylate; Iodine monochloride; In diethyl ether; chloroform-d1; dichloromethane;

DOI:10.1002/anie.201801976

upstream raw materials:

diethyl aminomalonate hydrochloride

3-dimethylaminopropiophenone

acetophenone

1-(1-azido-2-iodoethyl)benzene

Downstream raw materials:

5-phenyl pyrrole-1,2-dicarboxylate de diethyle

5-phenyl pyrrole-2,3-dicarboxylate de diethyle