N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide

Base Information

• Chemical Name: N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide
• CAS No.: 247186-85-2
• Molecular Formula: C₁₅H₁₄N₂O₃S
• Molecular Weight: 302.354
• Mol file: 247186-85-2.mol

Synonyms:N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide

Chemical Property of N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide

There total 15 articles about N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-methoxy-N-(1-(pyrimidin-2-yl)-1H-indol-7-yl)-benzenesulfonamide → N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide (247186-85-2)

Guidance literature:

With sodium ethanolate; In ethanol; dimethyl sulfoxide; at 100 ℃; for 5h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.9b01893 DOI:10.1021/acs.joc.9b01893

Reference yield: 30.0%

7-nitro-1H-indole (6960-42-5) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide (247186-85-2)

Guidance literature:

7-nitro-1H-indole; With iron; ammonium chloride; In water; isopropyl alcohol; at 60 ℃; for 2h;

4-methoxy-phenyl-sulphonyl chloride; With pyridine; In water; ethyl acetate; isopropyl alcohol; at 20 ℃; for 3h;

Reference yield:

7-nitro-1H-indole (6960-42-5) → N-(1H-indol-7-yl)-4-methoxybenzenesulfonamide (247186-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / methanol / 760 Torr

2: pyridine / ethyl acetate / 5 h

With pyridine; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; 1: Catalytic hydrogenation / 2: Sufonylation;

DOI:10.1021/jm9902638

upstream raw materials:

7-aminoindole

4-methoxy-phenyl-sulphonyl chloride

7-bromo-1H-indole

2-nitrophenyl bromide

Downstream raw materials:

N-(5,8-dimethyl-9H-carbazol-1-yl)-4-methoxybenzenesulfonamide

(N-(5,8-Dimethyl-9H carbazol-1-yl)-N-methyl-4-methoxybenzenesulfonamide)

(N-(5,8-Dimethyl-9H-carbazol-1-yl)-N-propyl-4-methoxybenzenesulfonamide)

(N-(5,8-Dimethyl-9H-carbazol-1-yl)-N-isopropyl-4-methoxybenzenesulfonamide)