3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

Base Information

Chemical Name:3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester
CAS No.:1426243-45-9
Molecular Formula:C₂₀H₂₅F₃O₅
Molecular Weight:402.411
Hs Code.:

Synonyms:3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

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Chemical Property of 3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

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Technology Process of 3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

There total 2 articles about 3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1426243-44-8
3-hydroxy-3-(trifluoromethyl)cyclobutane-1,1-dicarboxylic acid diisopropyl ester

: 100-39-0
benzyl bromide

: 1426243-45-9
3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 18h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201208069

Reference yield:

: 893724-10-2
dipropan-2-yl 3-oxocyclobutane-1,1-dicarboxylate

: 1426243-45-9
3-benzyloxy-3-trifluoromethyl-cyclobutane-1,1-dicarboxylic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: cesium fluoride / tetrahydrofuran / 15 h / 25 °C / Inert atmosphere; Cooling with ice; Schlenk technique

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 18 h / 0 °C / Inert atmosphere; Schlenk technique

With sodium hydride; cesium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201208069