benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

Base Information

Chemical Name:benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester
CAS No.:799257-24-2
Molecular Formula:C₂₁H₂₉F₂NO₇
Molecular Weight:445.461
Hs Code.:

Synonyms:benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

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Chemical Property of benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

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Technology Process of benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

There total 5 articles about benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 98-88-4
benzoyl chloride

: 799257-21-9
[1-(2,2-dimethyl[1,3]dioxolanan-4-yl)-2,2-difluoro-3,4-dihydroxybutyl]carbamic acid tert-butyl ester

: 799257-24-2
benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

Guidance literature:: With pyridine; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/ol048423j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 799257-24-2
benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / CH₂Cl₂ / 10 h / 20 °C

2: 45 percent / NMNO; OsO₄ / acetone; H₂O / 48 h / 20 °C

3: 84 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; In dichloromethane; water; acetone;
DOI:10.1021/ol048423j

Reference yield:

: 799257-15-1
1-(2,2-dimethyl[1,3]dioxolanan-4-yl)-2,2-difluorobut-3-enylamine

: 799257-24-2
benzoic acid 4-tert-butoxycarbonylamino-4-(2,2-dimethyl[1,3]dioxolanan-4-yl)-3,3-difluoro-2-hydroxybutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / CH₂Cl₂ / 10 h / 20 °C

2: 45 percent / NMNO; OsO₄ / acetone; H₂O / 48 h / 20 °C

3: 84 percent / pyridine / CH₂Cl₂ / 2 h / -78 °C

With pyridine; osmium(VIII) oxide; bis-(2-chloro-ethyl)-methyl-amine oxide; In dichloromethane; water; acetone;
DOI:10.1021/ol048423j