2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide

Base Information

• Chemical Name: 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide
• CAS No.: 365572-13-0
• Molecular Formula: C₂₄H₃₂BrNO₄
• Molecular Weight: 478.426
• Mol file: 365572-13-0.mol

Synonyms:2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide

Chemical Property of 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide

There total 5 articles about 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyric acid (365572-12-9) → 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide (365572-13-0)

Guidance literature:

2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyric acid; With thionyl chloride; In dichloromethane; at 0 ℃; for 2h;

With ammonia; In formamide; at 0 ℃; for 1h;

DOI:10.1002/jhet.5570390609

Reference yield:

1-(2-Bromoethyl)-4-(1-methylethoxy)benzene (365572-09-4) → 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide (365572-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 82 percent / potassium carbonate / dimethylformamide / 10 h / 70 °C

2.1: 95 percent / potassium carbonate / dimethylformamide / 12 h / 60 °C

3.1: aq. KOH / ethanol / 12 h / Heating

3.2: 94 percent / 0.5 h / 140 °C / 0 Torr

4.1: thionyl chloride / CH₂Cl₂ / 2 h / 0 °C

4.2: 92 percent / ammonia / formamide / 1 h / 0 °C

With potassium hydroxide; thionyl chloride; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570390609

Reference yield:

2-[2-[4-(1-methylethoxy)phenyl]ethyl]propanedioic acid dimethyl ester (365572-10-7) → 2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide (365572-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 95 percent / potassium carbonate / dimethylformamide / 12 h / 60 °C

2.1: aq. KOH / ethanol / 12 h / Heating

2.2: 94 percent / 0.5 h / 140 °C / 0 Torr

3.1: thionyl chloride / CH₂Cl₂ / 2 h / 0 °C

3.2: 92 percent / ammonia / formamide / 1 h / 0 °C

With potassium hydroxide; thionyl chloride; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570390609

upstream raw materials:

2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyric acid

1-(2-Bromoethyl)-4-(1-methylethoxy)benzene

2-[2-[4-(1-methylethoxy)phenyl]ethyl]propanedioic acid dimethyl ester

2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester

Downstream raw materials:

α-(2-bromo-5-hydroxy-4-methoxyphenylmethyl)-4-hydroxy-benzenebutaneamide