2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester

Base Information

• Chemical Name: 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester
• CAS No.: 365572-11-8
• Molecular Formula: C₂₇H₃₅BrO₇
• Molecular Weight: 551.475
• Mol file: 365572-11-8.mol

Synonyms:2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester

Chemical Property of 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester

There total 3 articles about 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-2-(chloromethyl)-5-methoxy-4-(1-methylethoxy)benzene (365572-07-2) + 2-[2-[4-(1-methylethoxy)phenyl]ethyl]propanedioic acid dimethyl ester (365572-10-7) → 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester (365572-11-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 12h;

DOI:10.1002/jhet.5570390609

Reference yield:

malonic acid dimethyl ester (108-59-8) → 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester (365572-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / potassium carbonate / dimethylformamide / 10 h / 70 °C

2: 95 percent / potassium carbonate / dimethylformamide / 12 h / 60 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570390609

Reference yield:

1-(2-Bromoethyl)-4-(1-methylethoxy)benzene (365572-09-4) → 2-[2-bromo-4-methoxy-5-(1-methylethoxy)phenylmethyl]-2-[2-[4-(1-methylethoxy)-phenyl]ethyl]propanediacid dimethyl ester (365572-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / potassium carbonate / dimethylformamide / 10 h / 70 °C

2: 95 percent / potassium carbonate / dimethylformamide / 12 h / 60 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570390609

upstream raw materials:

1-bromo-2-(chloromethyl)-5-methoxy-4-(1-methylethoxy)benzene

2-[2-[4-(1-methylethoxy)phenyl]ethyl]propanedioic acid dimethyl ester

malonic acid dimethyl ester

1-(2-Bromoethyl)-4-(1-methylethoxy)benzene

Downstream raw materials:

2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyramide

α-(2-bromo-5-hydroxy-4-methoxyphenylmethyl)-4-hydroxy-benzenebutaneamide

2-(2-bromo-5-isopropoxy-4-methoxybenzyl)-4-(4-isopropoxyphenyl)butyric acid