(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Base Information

Chemical Name:(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate
CAS No.:948842-90-8
Molecular Formula:C₃₅H₃₉N₇O₈
Molecular Weight:685.737
Hs Code.:

(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Synonyms:(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

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Chemical Property of (S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

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Technology Process of (S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

There total 6 articles about (S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 948842-84-0
iodomethyl 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl(propyl)carbamate

: 948864-15-1
silver salt of (S)-2-(benzyloxycarbonylamino)propanoic acid

: 948842-90-8
(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

: 623152-17-0
BMS-582949

: 948842-90-8
(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / N,N-dimethyl-formamide / 60 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -45 °C

2.2: -45 - 20 °C

3.1: sodium iodide / acetone / Reflux

4.1: toluene / Reflux

With dmap; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.022

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 948842-90-8
(S)-((4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl 2-(benzyloxycarbonyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: silver nitrate; sodium hydroxide

2: toluene / Reflux

With silver nitrate; sodium hydroxide; In toluene;
DOI:10.1016/j.bmcl.2013.03.022