(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Base Information

Chemical Name:(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate
CAS No.:1380606-18-7
Molecular Formula:C₁₆H₂₂ClNO₃
Molecular Weight:311.809
Hs Code.:

Synonyms:(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

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Technology Process of (+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

There total 5 articles about (+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 1380606-17-6
(+/-)-tert-Butyl 1-{[3-(benzylamino)-4-chlorophenyl](methoxy)methyl}cyclopropanecarboxylate

: 1380606-18-7
(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 24h; under 760.051 Torr;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380606-18-7
(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.67 h / 10 - 20 °C

3.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 110 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 760.05 Torr

With n-butyllithium; hydrogen; sodium hydride; diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 86265-88-5
3-bromo-4-chloro-benzaldehyde

: 1380606-18-7
(+/-)-tert-Butyl 1-[(3-amino-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.67 h / 10 - 20 °C

3.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 110 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 24 h / 20 °C / 760.05 Torr

With n-butyllithium; hydrogen; sodium hydride; diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;