(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Base Information

Chemical Name:(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate
CAS No.:1380606-16-5
Molecular Formula:C₁₆H₂₀BrClO₃
Molecular Weight:375.69
Hs Code.:

Synonyms:(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

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Chemical Property of (+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Chemical Property:

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Technology Process of (+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

There total 2 articles about (+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 1380606-15-4
(+/-)-tert-Butyl 1-[(3-bromo-4-chlorophenyl)(hydroxy)methyl]cyclopropanecarboxylate

: 74-88-4
methyl iodide

: 1380606-16-5
(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 10 - 20 ℃; for 1.66667h;

Reference yield:

: 87661-20-9
tert-butyl cyclopropanecarboxylate

: 1380606-16-5
(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.67 h / 10 - 20 °C

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;

Reference yield: 74.8%

: 1380606-16-5
(+/-)-tert-butyl 1-[(3-bromo-4-chlorophenyl)(methoxy)methyl]cyclopropanecarboxylate

: 100-46-9
benzylamine

: 1380606-17-6
(+/-)-tert-Butyl 1-{[3-(benzylamino)-4-chlorophenyl](methoxy)methyl}cyclopropanecarboxylate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 3h; Inert atmosphere;