2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

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Chemical Name:2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran
CAS No.:289472-27-1
Molecular Formula:C₂₈H₃₈O₆
Molecular Weight:470.606
Hs Code.:

Synonyms:2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

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Chemical Property of 2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

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Technology Process of 2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

There total 6 articles about 2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 139896-11-0,126822-64-8
(Z)-<2-methyl-3-(2-tetrahydropyranyloxy)-1-propenyl>trimethylstannane

: 289472-25-9
2-Bromomethyl-1,3-bis-methoxymethoxy-5-phenethyl-benzene

: 289472-27-1
2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; In 1,2-dimethoxyethane; at 85 ℃; for 24h;
DOI:10.1016/S0040-4039(00)00676-6

Reference yield:

: 78916-50-4
1,3-dimethoxy-5-(2-phenylethyl)benzene

: 289472-27-1
2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: sec-BuLi; TMEDA / tetrahydrofuran

1.2: 91 percent / tetrahydrofuran

2.1: 77 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -78 °C

3.1: NaH / tetrahydrofuran / 1 h / 20 °C

4.1: LiAlH₄

5.1: PBr₃; pyridine / diethyl ether / 0.5 h / 0 °C

6.1: 56 percent / Pd₂(dba)3*CHCl₃; AsPh₃ / 1,2-dimethoxy-ethane / 24 h / 85 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; N,N,N,N,-tetramethylethylenediamine; triphenyl-arsane; sec.-butyllithium; boron tribromide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 1.1: Metallation / 1.2: Formylation / 2.1: demethylation / 3.1: Alkylation / 4.1: Reduction / 5.1: Bromination / 6.1: Stille coupling;
DOI:10.1016/S0040-4039(00)00676-6

Reference yield:

: 289472-07-7
2,6-dimethoxy-4-(2-phenylethyl)benzaldehyde

: 289472-27-1
2-[(Z)-4-(2,6-Bis-methoxymethoxy-4-phenethyl-phenyl)-2-methyl-but-2-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / BBr₃ / CH₂Cl₂ / 0.5 h / -78 °C

2: NaH / tetrahydrofuran / 1 h / 20 °C

3: LiAlH₄

4: PBr₃; pyridine / diethyl ether / 0.5 h / 0 °C

5: 56 percent / Pd₂(dba)3*CHCl₃; AsPh₃ / 1,2-dimethoxy-ethane / 24 h / 85 °C

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; triphenyl-arsane; boron tribromide; phosphorus tribromide; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 1: demethylation / 2: Alkylation / 3: Reduction / 4: Bromination / 5: Stille coupling;
DOI:10.1016/S0040-4039(00)00676-6