((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Base Information

• Chemical Name: ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester
• CAS No.: 200949-24-2
• Molecular Formula: C₄₇H₆₀N₈O₁₀
• Molecular Weight: 897.041

Synonyms:((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Chemical Property of ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Chemical Property:

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Technology Process of ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

There total 4 articles about ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Boc-D-Phe-OH (18942-49-9) + ((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-carbamoyl-butyrylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (748735-07-1) → ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (200949-24-2)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0223-5234(99)80063-4

Reference yield:

((S)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (771441-12-4) → ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (200949-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / BOP, N-methylmorpholine / dimethylformamide / 2 h / Ambient temperature

2: 91 percent / Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

3: 89 percent / BOP, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(99)80063-4

Reference yield:

((S)-2-{(S)-2-[(S)-2-[(S)-4-Carbamoyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (200949-23-1) → ((S)-2-{(S)-2-[(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-carbamoyl-butyrylamino]-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester (200949-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

2: 89 percent / BOP, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(99)80063-4

upstream raw materials:

Boc-D-Phe-OH

((S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-carbamoyl-butyrylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

((S)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Downstream raw materials:

Boc-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-β-homo-Leu-NH2

Boc-D-Phe-Gln-Trp-Ala-Val-Gly-His-β-homo-Leu-D-Nle-NH2

Boc-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-Aic-NH₂

Boc-D-Phe-Gln-Trp-Ala-Val-Gly-His-LeuΨ(CH2NH)Leu-NH2

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