NH₂-Val-Ala-Phe-COOMe

Base Information

• Chemical Name: NH₂-Val-Ala-Phe-COOMe
• CAS No.: 1027174-07-7
• Molecular Formula: C₁₈H₂₇N₃O₄
• Molecular Weight: 349.43
• Mol file: 1027174-07-7.mol

Synonyms:NH₂-Val-Ala-Phe-COOMe

Chemical Property of NH₂-Val-Ala-Phe-COOMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of NH₂-Val-Ala-Phe-COOMe

There total 5 articles about NH₂-Val-Ala-Phe-COOMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Val-Ala-Phe-OMe (197781-20-7) → NH2-Val-Ala-Phe-COOMe (1027174-07-7)

Guidance literature:

With formic acid; for 8h;

DOI:10.1039/a700624a

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → NH2-Val-Ala-Phe-COOMe (1027174-07-7)

Guidance literature:

Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

2: 100 percent / trifluoroacetic acid; anisole / CH₂Cl₂

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

4: trifluoroacetic acid; anisole / CH₂Cl₂

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2006.04.031

Reference yield:

N-tert-butyloxycarbonylalanylphenylalanine methyl ester (2280-66-2) → NH2-Val-Ala-Phe-COOMe (1027174-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / trifluoroacetic acid; anisole / CH₂Cl₂

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

3: trifluoroacetic acid; anisole / CH₂Cl₂

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2006.04.031

upstream raw materials:

Boc-Val-Ala-Phe-OMe

methyl (2S)-2-amino-3-phenylpropanoate

L-alanyl-L-phenylalanine methyl ester

N-tert-butyloxycarbonylalanylphenylalanine methyl ester

Downstream raw materials:

C₂₅H₂₉N₃O₅Se

(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-propionylamino)-3-phenyl-propionic acid methyl ester