N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester

Base Information

Chemical Name:N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester
CAS No.:197781-20-7
Molecular Formula:C₂₃H₃₅N₃O₆
Molecular Weight:449.547
Hs Code.:
DSSTox Substance ID:DTXSID501137300

Synonyms:DTXSID501137300;N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester;197781-20-7

Suppliers and Price of N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:449.25258584
Heavy Atom Count:32
Complexity:653

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C(C(=O)NC(C)C(=O)NC(CC1=CC=CC=C1)C(=O)OC)NC(=O)OC(C)(C)C
Isomeric SMILES:C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C

Technology Process of N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester

There total 7 articles about N-[(1,1-Dimethylethoxy)carbonyl]-L-valyl-L-alanyl-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 70396-18-8
(2S)-2-((2S)-2-[(tert-butoxy)carbonyl]amino-3-methylbutyrylamino)propionic acid

: 197781-20-7
Boc-Val-Ala-Phe-OMe

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 72h;
DOI:10.1039/a700624a

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 87892-68-0
methyl L-alanyl-L-phenylalanine trifluoroacetate

: 197781-20-7
Boc-Val-Ala-Phe-OMe

Guidance literature:: t-Boc-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

L-Ala-L-Phe-OMe trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol5002126

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 40298-89-3,97336-13-5,102606-46-2,127214-08-8
L-alanyl-L-phenylalanine methyl ester

: 197781-20-7
Boc-Val-Ala-Phe-OMe

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.04.031