4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester

Base Information

• Chemical Name: 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester
• CAS No.: 149324-72-1
• Molecular Formula: C₁₅H₂₂O₅S
• Molecular Weight: 314.403
• Mol file: 149324-72-1.mol

Synonyms:4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester

Chemical Property of 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester

There total 8 articles about 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanesulfonyl chloride (124-63-0) + tert-Butyl 4-(3-hydroxy-1-propyl)benzoate (126931-32-6) → 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester (149324-72-1)

Guidance literature:

With triethylamine;

DOI:10.1021/jo00129a040

Reference yield:

4-(tert-butoxycarbonyl)benzaldehyde (65874-27-3) → 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester (149324-72-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

2: H₂ / 10percent Pd/C

3: 1N aq. NaOH / ethanol / 3 h / Ambient temperature

4: 97 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / Ambient temperature

5: 45 g / triethylamine / CH₂Cl₂ / 1 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00037a012

Reference yield:

ethyl 3-<4-(tert-butoxycarbonyl)phenyl>acrylate (149325-50-8) → 4-(3-Methanesulfonyloxy-propyl)-benzoic acid tert-butyl ester (149324-72-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C

2: 1N aq. NaOH / ethanol / 3 h / Ambient temperature

3: 97 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / Ambient temperature

4: 45 g / triethylamine / CH₂Cl₂ / 1 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00037a012

upstream raw materials:

methanesulfonyl chloride

tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

4-iodobenzoic acid

tert-butyl 4-iodobenzoate

Downstream raw materials:

tert-butyl 4-(3-iodopropyl)benzoate

4-<3-<2-<<(N,N-Dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoic acid

tert-Butyl 4-<3-<2-<<(N,N-dimethylamino)methylene>amino>-3-<(pivaloyloxy)methyl>-4(3H)-oxo-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoate

Dimethyl N-<4-<3-<2-<<(N,N-dimethylamino)methylene>amino>-4(3H)-oxo-3-<(pivaloyloxy)methyl>-5H-pyrrolo<3,2-d>pyrimidin-5-yl>propyl>benzoyl>-L-glutamate