acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester

Base Information

• Chemical Name: acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester
• CAS No.: 934832-08-3
• Molecular Formula: C₂₄H₂₁FN₆O₃
• Molecular Weight: 460.468

Synonyms:acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester

Chemical Property of acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester

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Technology Process of acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester

There total 2 articles about acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol (934832-07-2) + acetyl chloride (75-36-5) → acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester (934832-08-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmcl.2007.01.002

Reference yield:

4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazine-5-carboxylic acid methyl ester → acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester (934832-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / LiAlH₄ / tetrahydrofuran / 0 - 20 °C

2: 75 percent / DIPEA / CH₂Cl₂ / 0 °C

With lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.002

Reference yield:

acetic acid 4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl ester (934832-08-3) → [1-(3-fluoro-benzyl)-1H-indazol-5-yl]-[6-methoxy-5-(morpholin-2-ylmethoxymethyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl]-amine

Guidance literature:

Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 18 h / 85 °C

2: TFA / 1,2-dichloro-ethane

With trifluoroacetic acid; In 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2007.01.002

upstream raw materials:

{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-6-methoxy-pyrrolo[2,1-f][1,2,4]triazin-5-yl}-methanol

acetyl chloride

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