934832-07-2Relevant academic research and scientific papers
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases
Mastalerz, Harold,Chang, Ming,Chen, Ping,Dextraze, Pierre,Fink, Brian E.,Gavai, Ashvinikumar,Goyal, Bindu,Han, Wen-Ching,Johnson, Walter,Langley, David,Lee, Francis Y.,Marathe, Punit,Mathur, Arvind,Oppenheimer, Simone,Ruediger, Edward,Tarrant, James,Tokarski, John S.,Vite, Gregory D.,Vyas, Dolatrai M.,Wong, Henry,Wong, Tai W.,Zhang, Hongjian,Zhang, Guifen
, p. 2036 - 2042 (2007)
Novel C-5 substituted pyrrolotriazines were optimized for dual EGFR and HER2 protein tyrosine kinase inhibition. The lead compound exhibited promising oral efficacy in both EGFR and HER2 driven human tumor xenograft models. It is hypothesized that its C-5
