(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

Base Information

Chemical Name:(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile
CAS No.:1000333-97-0
Molecular Formula:C₂₂H₂₀N₂O
Molecular Weight:328.414
Hs Code.:

Synonyms:(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

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Chemical Property of (2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

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Technology Process of (2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

There total 5 articles about (2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1000333-92-5
2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-one

: 1000333-97-0
(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-one; In tetrahydrofuran; for 0.5h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield:

: 81945-13-3
4-bromo-7-hydroxy-2,3-dihydro-1H-inden-1-one

: 1000333-97-0
(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid; acetic anhydride / acetic acid / 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

3.1: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.1: pyridinium p-toluenesulfonate / xylene / 3 h / Heating / reflux

5.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

5.2: 0.5 h

With diethyl cyanophosphonate; hydrogen; nitric acid; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; xylene;

Reference yield:

: 50663-21-3
(para-bromophenyl)-2-propenoate

: 1000333-97-0
(2-(4-phenylbutyl)-6,7-dihydro-8H-indeno[5,4-d][1,3]oxazol-8-ylidene)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride; sodium chloride / 1 h / 100 - 140 °C

2.1: nitric acid; acetic anhydride / acetic acid / 3 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

4.1: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.1: pyridinium p-toluenesulfonate / xylene / 3 h / Heating / reflux

6.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

6.2: 0.5 h

With aluminum (III) chloride; diethyl cyanophosphonate; hydrogen; nitric acid; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; triethylamine; sodium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; xylene;