4-BROMOCINNAMIC ACID

Base Information

• Chemical Name: 4-BROMOCINNAMIC ACID
• CAS No.: 50663-21-3
• Molecular Formula: C9H7BrO2
• Molecular Weight: 227.057
• Hs Code.: 2916399090
• Mol file: 50663-21-3.mol

Synonyms:4-Bromophenylacrylate;p-Bromophenyl acrylate;

Chemical Property of 4-BROMOCINNAMIC ACID

Chemical Property:

• Vapor Pressure: 2.43E-05mmHg at 25°C
• Melting Point: 262 °C
• Refractive Index: 1.5627 (estimate)
• Boiling Point: 344.9 °C at 760 mmHg
• Flash Point: 162.4 °C
• PSA: 37.30000
• Density: 1.607 g/cm³
• LogP: 2.54690

Purity/Quality:

99% ^*data from raw suppliers

4-BromophenylAcrylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMOCINNAMIC ACID

There total 7 articles about 4-BROMOCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acryloyl chloride (814-68-6,25189-84-8) → (para-bromophenyl)-2-propenoate (50663-21-3)

Guidance literature:

4-bromo-phenol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

acryloyl chloride; In tetrahydrofuran; at 0 ℃; for 0.25h;

Reference yield: 86.0%

4-bromo-phenol (106-41-2) + acryloyl chloride (814-68-6,25189-84-8) → (para-bromophenyl)-2-propenoate (50663-21-3)

Guidance literature:

4-bromo-phenol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

acryloyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/jacs.8b08605

Reference yield: 63.0%

4-bromo-phenol (106-41-2) + acrylic acid (79-10-7) → (para-bromophenyl)-2-propenoate (50663-21-3)

Guidance literature:

acrylic acid; With thionyl chloride; for 0.5h; Reflux;

4-bromo-phenol; In dichloromethane; for 1h; Reflux;

DOI:10.1002/bkcs.10067

upstream raw materials:

4'-bromophenyl 3-bromopropionate

4'-bromophenyl 3-bromopropionate-2-d

4-bromo-phenol

acryloyl chloride

Refernces

• 1、 Das, Animesh,Jana, Akash,Maji, Biplab. "Palladium-catalyzed remote C-H functionalization of 2-aminopyrimidines". supporting information. p. 4284 - 4287. Retrieved 2020/04/27.
• 2、 Rai, Pramod,Maji, Kakoli,Maji, Biplab. "Photoredox/Cobalt Dual Catalysis for Visible-Light-Mediated Alkene-Alkyne Coupling". supporting information. p. 3755 - 3759. Retrieved 2019/05/24.