3,4,5-TRIBROMOPYRIDINE

Base Information

• Chemical Name: 3,4,5-TRIBROMOPYRIDINE
• CAS No.: 2457-48-9
• Molecular Formula: C5H2Br3N
• Molecular Weight: 315.79
• Hs Code.: 2933399090
• Mol file: 2457-48-9.mol

Synonyms:3,4,5-tribromo-pyridine;3,4,5-Tribromopyridin;3,4,5-Tribrompyridin;

Chemical Property of 3,4,5-TRIBROMOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.00523mmHg at 25°C
• Melting Point: 106.5-107.5oC
• Refractive Index: 1.642
• Boiling Point: 284.021 °C at 760 mmHg
• PKA: 0.77±0.10(Predicted)
• Flash Point: 125.572 °C
• PSA: 12.89000
• Density: 2.407 g/cm³
• LogP: 3.36910
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4,5-Tribromopyridine, 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4,5-TRIBROMOPYRIDINE

There total 1 articles about 3,4,5-TRIBROMOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridin-4-ol (626-64-2,157061-69-3) → 3,4,5-tribromopyridine (2457-48-9) + 4-bromopyridin (1120-87-2)

Guidance literature:

With phosphorus pentabromide; at 110 ℃;

Reference yield: 95.0%

methanol (67-56-1) + 3,4,5-tribromopyridine (2457-48-9) → 3,5-dibromo-4-methoxypyridine (25813-24-5)

Guidance literature:

methanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

3,4,5-tribromopyridine; In tetrahydrofuran; at 20 ℃; for 19h;

Reference yield:

3,4,5-tribromopyridine (2457-48-9) → N-(4-(5-bromo-4-methoxypyridin-3-yl)-3-methylphenyl)methanesulfonamide (1357093-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

1.2: 19 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 1 h / 90 °C / Inert atmosphere

With sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water;

upstream raw materials:

pyridin-4-ol

Downstream raw materials:

2,3,4,5-tetrabromo-pyridine

pentabromopyridine

2,3,5-tribromo-[4]pyridylamine

3,5-dibromo-4-methoxypyridine