4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

Base Information

Chemical Name:4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide
CAS No.:139260-70-1
Molecular Formula:C₂₉H₃₃N₃O₅S
Molecular Weight:535.664
Hs Code.:

Synonyms:4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

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Chemical Property of 4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

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Technology Process of 4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

There total 9 articles about 4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 139260-70-1
4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / CH₂Cl₂ / 18 h / Ambient temperature

2: SOCl₂ / 1.5 h / Heating

3: CH₂Cl₂ / 18 h / Ambient temperature

4: 49.5 percent / diethyl ether / 18 h / Ambient temperature

5: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

With n-butyllithium; thionyl chloride; In diethyl ether; dichloromethane;
DOI:10.1039/P19910003165

Reference yield:

: 59-67-6
nicotinic acid

: 139260-70-1
4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 18 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 1) lithium diisopropylamide / 1) Et₂O, -70 deg C, 2 h; 2) Et₂O, -50 deg C, then 18 h at room temp.

4: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

With n-butyllithium; thionyl chloride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1039/P19910003165

Reference yield:

: 10400-19-8
3-pyridinecarbonyl chloride

: 139260-70-1
4-<1-Hydroxy-1-(5-methoxy-1-phenylsulphonylindol-2-yl)-ethyl>-N,N-diisopropylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂ / 18 h / Ambient temperature

2: 1) lithium diisopropylamide / 1) Et₂O, -70 deg C, 2 h; 2) Et₂O, -50 deg C, then 18 h at room temp.

3: 1) BuLi / 1) THF, room temp., 2 h; 2) THF, -13 deg C, then 18 h at room temp.

With n-butyllithium; lithium diisopropyl amide; In dichloromethane;
DOI:10.1039/P19910003165