3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Chemical Name:3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester
CAS No.:489464-16-6
Molecular Formula:C₅₂H₆₁N₇O₁₁
Molecular Weight:960.097
Hs Code.:

3-{benzyloxy-[1-({2-[2-(<i>N</i>'-<i>tert</i>-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9<i>H</i>-fluoren-9-ylmethyl) ester

Synonyms:3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of 3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

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Technology Process of 3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

There total 6 articles about 3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 160885-39-2
(R)-3-[Benzyloxy-((S)-1-carboxy-ethyl)-carbamoyl]-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

: 489464-15-5
N'-[1-(2-methylamino-propionyl)-pyrrolidine-2-carbonyl]-hydrazinecarboxylic acid tert-butyl ester

: 489464-16-6
3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at -20 - 0 ℃; for 1.83333h;
DOI:10.1039/b204018b

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 489464-16-6
3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / DCC / tetrahydrofuran / 24 h / 0 - 20 °C

2: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 12 h / 20 °C

3: 93 percent / AgCN / benzene / 0.83 h / 80 °C

4: 94 percent / Et₂NH / acetonitrile / 0.42 h / 20 °C

5: 89 percent / BOPCl; Et₃N / CH₂Cl₂ / 1.83 h / -20 - 0 °C

With silver cyanide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; dicyclohexyl-carbodiimide; 20percent Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1039/b204018b

Reference yield:

: 53157-64-5
Z-Pro-NHNHBoc

: 489464-16-6
3-{benzyloxy-[1-({2-[2-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl}-methyl-carbamoyl)-ethyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 20percent Pd(OH)2/C / methanol / 12 h / 20 °C

2: 93 percent / AgCN / benzene / 0.83 h / 80 °C

3: 94 percent / Et₂NH / acetonitrile / 0.42 h / 20 °C

4: 89 percent / BOPCl; Et₃N / CH₂Cl₂ / 1.83 h / -20 - 0 °C

With silver cyanide; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; triethylamine; 20percent Pd(OH)2/C; In methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1039/b204018b